منابع مشابه
The mechanical integrin cycle.
Cells govern tissue shape by exerting highly regulated forces at sites of matrix adhesion. As the major force-bearing adhesion-receptor protein, integrins have a central role in how cells sense and respond to the mechanics of their surroundings. Recent studies have shown that a key aspect of mechanotransduction is the cycle by which integrins bind to the matrix at the leading cell edge, attach ...
متن کاملThe switchable integrin adhesome.
Adhesion sites, which interconnect cells with their neighbors or with the extracellular matrix (ECM), are large multiprotein complexes that provide mechanical coupling as well as a means for cells to sense the chemical and physical properties of their environment (Bershadsky et al., 2003; Chen et al., 2004; Geiger et al., 2001; Sastry and Burridge, 2000). The complex interplay between the mecha...
متن کاملThe integrin reconstruction act
The integrin reconstruction act " I n biology, you really know what you're talking about when you can reconstruct a system synthetically, " says Mark Ginsberg from UC San Diego. That hasn't been possible in the case of integrin activation—the process by which integrin adhesion receptors gain an increased affi nity for their extracellular matrix ligands. The activation mechanism has been highly ...
متن کاملPhosphorylation of the Integrin
4 integrins are essential for embryogenesis, hematopoiesis, inflammation, and immune response possibly because 4 integrins have distinct signaling properties from other integrins. Specifically, the 4 cytoplasmic domain binds tightly to paxillin, a signaling adaptor protein, leading to increased cell migration and an altered cytoskeletal organization that results in reduced cell spreading. The 4...
متن کاملIntegrin traffic – the update
Integrins are a family of transmembrane cell surface molecules that constitute the principal adhesion receptors for the extracellular matrix (ECM) and are indispensable for the existence of multicellular organisms. In vertebrates, 24 different integrin heterodimers exist with differing substrate specificity and tissue expression. Integrin-extracellular-ligand interaction provides a physical anc...
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ژورنال
عنوان ژورنال: Journal of Biomechanics
سال: 2010
ISSN: 0021-9290
DOI: 10.1016/j.jbiomech.2009.09.007